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Related Experiment Video

Updated: Jul 14, 2026

Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses

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Brain-immune communication pathways.

Ning Quan¹, William A Banks

¹Institute of Behavioral Medicine, Ohio State University, USA.

Brain, Behavior, and Immunity

|July 3, 2007

Summary

The neuroimmune axis facilitates communication between the central nervous and immune systems. Understanding its pathways, like neural routes and blood-brain barrier transport, reveals complex interactions.

Area of Science:

Neuroimmunology
Central Nervous System
Immune System

Background:

The neuroimmune axis describes the bidirectional communication between the nervous and immune systems.
Historically, conceptual hurdles have challenged the acceptance and understanding of this axis.

Observation:

The last two decades have seen significant advancements in understanding neuroimmune communication.
Key communication pathways include neural routes, circumventricular organs, and blood-brain barrier (BBB) transport of cytokines.

Findings:

Four primary pathways facilitate neuroimmune communication: neural, circumventricular organs, BBB cytokine transport, and BBB cell secretions.
These pathways confirm the existence of the neuroimmune axis.

Implications:

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Established pathways raise new questions regarding the intricate mechanisms and interactions within the neuroimmune axis.
Further research is needed to elucidate the functional interplay of these communication channels.