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Related Experiment Videos

Mapping the functional connectivity of anterior cingulate cortex.

Daniel S Margulies1, A M Clare Kelly, Lucina Q Uddin

  • 1The Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, 215 Lexington Avenue, 14th Floor, New York, NY 10016, USA.

Neuroimage
|July 3, 2007
PubMed
Summary
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The anterior cingulate cortex (ACC) has distinct functional subdivisions, including dorsal/ventral and rostral/caudal divisions. Resting-state connectivity reveals negative relationships between affective and attention networks within the ACC.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Functional Neuroimaging

Background:

  • The anterior cingulate cortex (ACC) is crucial for brain information processing and regulation.
  • ACC exhibits structural and functional heterogeneity, with established motor, cognitive, and affective subdivisions.
  • Resting-state functional connectivity offers insights into task-independent brain activity patterns.

Purpose of the Study:

  • To systematically map ACC functional connectivity during rest.
  • To investigate finer-grained functional segregation within the ACC beyond known distinctions.
  • To identify interactions between different ACC-based functional networks.

Main Methods:

  • Systematic mapping of resting-state functional connectivity.
  • Analysis of 16 seed regions of interest (ROIs) across caudal, rostral, and subgenual ACC in each hemisphere.

Related Experiment Videos

  • Examination of functional correlations, including negative relationships and interhemispheric connectivity.

    • Main Results:

    • Confirmed rostral/caudal ACC distinction and revealed a novel dorsal/ventral functional segregation.
    • Identified more detailed functional differentiation within ACC subdivisions than previously appreciated.
    • Demonstrated negative correlations between rostral ACC-related affective networks and dorsal-caudal ACC-related attention networks.
    • Observed stronger correlations between homologous interhemispheric regions.

    Conclusions:

    • The ACC exhibits a more complex functional organization than commonly recognized.
    • Distinct ACC networks, particularly affective and attention networks, exhibit antagonistic relationships.
    • Findings have implications for understanding ACC function and potential clinical applications.