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Updated: Jun 23, 2026
07:27
Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Published on: April 30, 2010
Need for speed: mechanical regulation of a replicative helicase
1Department of Physics and Institute for Genomic Biology, University of Illinois, Urbana-Champaign, and Howard Hughes Medical Institute, Urbana, IL 61801, USA. tjha@uiuc.edu
Cell
|July 3, 2007
Abstract:
There is much debate about how helicases unwind DNA during DNA replication and how their activity is regulated. In this issue, Johnson et al. (2007) shed light on this conundrum using a single molecule approach to dissect the behavior of the T7 DNA helicase.
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