Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxidative stress modulation and T cell activation.

Anis Larbi1, Juergen Kempf, Graham Pawelec

  • 1Center for Medical Research, Tuebingen Ageing and Tumor Immunology group, University of Tuebingen, Waldhornlestrasse 22, 72072 Tuebingen, Germany. anis.larbi@medizin.uni-tuebingen.de

Experimental Gerontology
|July 3, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Omics signature of new-onset mild cognitive impairment and dementia in a population-based study.

Scientific reports·2026
Same author

Multiplex profiling of 16 immune checkpoints identifies novel serum biomarker panels for breast cancer detection and TNBC stratification: A case-control study.

PloS one·2026
Same author

Breast and ovarian cancers: toward a multi-cancer early detection test.

Frontiers in immunology·2026
Same author

Comprehensive analysis of immune mediators in triple-negative breast cancer: Disclosing potential diagnostic and prognostic biomarkers.

Cytokine·2026
Same author

The SG90 cohort of the oldest-old in Singapore.

European journal of epidemiology·2025
Same author

An Update on Flow Cytometry Analysis of Hematological Malignancies: Focus on Standardization.

Cancers·2025

Oxidative stress from aerobic metabolism or hyperoxic cell culture can damage T cells and impair immune function. Modulating oxidative stress is crucial for preventing T cell dysfunction and maintaining immune health.

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • T cell function is vital for immunity but can be compromised by extrinsic factors.
  • Reactive oxygen species (ROS) contribute to DNA and protein damage, impacting T cell function.
  • Age-related immune dysfunction is linked to increased oxidative stress.

Purpose of the Study:

  • To discuss the role of oxidative stress in T cell dysfunction.
  • To highlight the impact of hyperoxic conditions in T cell culturing.
  • To emphasize the importance of oxidative stress modulation for T cell health.

Main Methods:

  • Literature review on oxidative stress and T cell function.
  • Analysis of ROS generation during immune responses and cell culture.

Related Experiment Videos

  • Discussion of technical aspects of T cell culture under hyperoxia.

    • Main Results:

    • Imbalance in ROS production and antioxidant defenses severely affects T cell activation.
    • Hyperoxic cell culture conditions can contribute to oxidative stress.
    • Controlling extracellular oxidative stress can influence T cell signaling.

    Conclusions:

    • Oxidative stress modulation is relevant for preventing T cell dysfunction.
    • Technical considerations in T cell culture, particularly hyperoxia, are critical.
    • Understanding and managing oxidative stress is key to maintaining immune competence.