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Interplay among oxidants, antioxidants, and cytokines in skin disorders: present status and future considerations

Meital Portugal1, Vivian Barak, Isaac Ginsburg

  • 1Department of Pharmaceutics, School of Pharmacy, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 3, 2007
PubMed

Insights

This review explores how oxidants and cytokines interact in skin disorders. Understanding this interplay is key for developing new antioxidant and cytokine-targeting therapies for conditions like psoriasis and dermatitis.

Area of Science:

  • Dermatology
  • Immunology
  • Biochemistry

Background:

  • Skin disorders arise from complex physiological, immunological, environmental, and genetic factors.
  • Oxidants and cytokines are increasingly recognized as critical players in skin disease pathophysiology.
  • These factors influence conditions from UV damage and carcinogenesis to inflammatory diseases like psoriasis and atopic dermatitis.

Purpose of the Study:

  • To review the intricate cross-talk between oxidants and the cytokine network in various skin disorders.
  • To explore the potential benefits of oxidant-cytokine interactions in wound healing.
  • To discuss therapeutic strategies involving antioxidants and cytokine-neutralizing antibodies.

Main Methods:

  • Literature review focusing on the interplay of oxidants and cytokines.
  • Analysis of the role of these interactions in specific skin conditions.
  • Examination of current and potential therapeutic applications.

Main Results:

  • The interaction between oxidants and cytokines is implicated in the pathogenesis of numerous skin disorders.
  • This interplay may offer therapeutic benefits in wound healing and disease management.
  • Monitoring cytokine profiles aids in assessing injury severity and guiding treatment.

Conclusions:

  • The balance between oxidants and cytokines is crucial in skin health and disease.
  • Targeting this interaction holds promise for novel therapeutic interventions.
  • Future research should investigate synergistic effects of antioxidants and cytokines on Th1/Th2 networks.

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