Related Experiment Video
Updated: Jul 14, 2026
Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
Does implantation of sonomicrometry crystals alter regional cardiac muscle function?
Josef Korinek1, Jan Vitek, Partho P Sengupta
1Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Background:
Sonomicrometry is a gold standard in experimental studies on myocardial motion. However, limited information exists regarding mechanical and biochemical changes produced by sonomicrometry crystal (SC) insertion into the myocardial wall.
Methods:
In 10 open-chest pigs, we implanted SCs into the inner half of apical anterior and midposterior regions. Longitudinal strains (systolic lengthening, end-systolic, peak shortening, and postsystolic shortening strains) and strain rate (SR) measurements (peak systolic ejection and early and late diastolic SRs) were obtained by Doppler SR echocardiography along with troponin I levels measured from peripheral blood before and after SC insertion.
Results:
SR and strain parameters did not change significantly after SC implantation. Troponin I levels increased significantly from less than 0.010 to 0.129 +/- 0.138 microg/L (P < .005) after SC implantation.
Conclusions:
Our study demonstrates that despite biochemical evidence of myocardial injury, carefully implanted SCs do not alter systolic or diastolic regional myocardial function assessed by Doppler echocardiography.
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