[Progress in the management of nonhealing wounds with stem cell transplantation]

Nonhealing wounds which significantly impair the quality of life for millions of people and impart an enormous burden on society are a challenge to clinical medicine. Therefore, the study of healing chronic wounds is vitally important. In the last two decades, extensive study on stem cells and the potential clinical applications have provided new perspectives in the management of chronic wounds. Increased reports state the notable effectiveness of stem cells transplantation. In this review, we summarize the main mechanisms of the long lasting restoration of the nonhealing wounds and address tremendous increase in the understanding of stem cell transplantation applied in the nonhealing chronic wounds.