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Related Experiment Video

Updated: Jul 14, 2026

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation

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MR-guided focused ultrasound.

Wladyslaw M W Gedroyc¹, Ann Anstee

¹MRI, MRI Unit, St Marys Hospital, Praed Street, London W2 1NY, UK. w.gedroyc@imperial.ac.uk

Expert Review of Medical Devices

|July 4, 2007

Summary

High-intensity focused ultrasound combined with MRI guidance enables non-invasive tissue destruction in solid organs. This precise method overcomes variable tissue responses using real-time thermal imaging for accurate energy delivery.

Area of Science:

Medical Physics
Oncology
Radiology

Background:

High-intensity focused ultrasound (HIFU) offers non-invasive therapeutic potential.
Magnetic Resonance (MR) imaging provides excellent soft-tissue visualization and temperature monitoring.
Combining HIFU and MR guidance creates a powerful tool for targeted tissue ablation.

Purpose of the Study:

To describe the integration of high-intensity focused ultrasound with MR guidance for non-invasive tissue ablation.
To highlight the role of MR in accurate targeting, thermal mapping, and real-time monitoring.
To discuss current and emerging applications of MR-guided HIFU in solid organs.

Main Methods:

Utilizing high-resolution MR imaging for precise targeting of lesions within solid organs.

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Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

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Real-time Monitoring of High Intensity Focused Ultrasound (HIFU) Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound (HMIFU)

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Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

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Employing MR thermometry for near real-time monitoring of tissue temperature during ultrasound application.

Integrating HIFU energy deposition with MR feedback to control tissue response and ensure therapeutic efficacy.

Main Results:

Demonstrated successful non-invasive tissue destruction deep within solid organs.
Achieved accurate energy deposition through MR-guided targeting and thermal mapping.
Overcame variability in tissue response by utilizing real-time MR thermal imaging feedback.

Conclusions:

MR-guided HIFU is an effective non-invasive system for targeted tissue ablation.
The system allows for precise energy delivery and overcomes challenges associated with variable tissue responses.
Current applications include uterine fibroid treatment, with expanding potential in other solid organs.