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Cryptosporidium parvum-associated sclerosing cholangitis in a liver transplant patient
C M Denkinger1, P Harigopal, P Ruiz
1Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts 02215, USA. cdenking@bidmc.harvard.edu
Abstract:
Cryptosporidium parvum causes severe long-standing diarrhea in immunocompromised patients. Sclerosing cholangitis caused by C. parvum is a rare complication in transplant recipients. We report herein the presentation of Cryptosporidium-associated cholangitis in an adult liver transplant patient diagnosed by liver biopsy. The patient improved on treatment with azithromycin and paromomycin.
Insights
Cryptosporidium parvum can cause severe diarrhea, especially in immunocompromised individuals. A rare complication, Cryptosporidium-associated cholangitis, was observed in a liver transplant recipient and successfully treated.
Area of Science:
- Infectious Diseases
- Hepatology
- Transplant Medicine
Background:
- Cryptosporidium parvum is a known cause of prolonged diarrhea in immunocompromised patients.
- Sclerosing cholangitis is a rare but serious complication in organ transplant recipients.
- Early diagnosis and treatment are crucial for managing opportunistic infections post-transplant.
Observation:
- A case of Cryptosporidium-associated cholangitis was identified in an adult liver transplant recipient.
- Diagnosis was confirmed through liver biopsy, revealing parasitic involvement.
- The patient presented with symptoms indicative of biliary tract infection.
Findings:
- The liver biopsy confirmed the presence of Cryptosporidium parvum in the biliary system.
- The patient showed clinical improvement following treatment with azithromycin and paromomycin.
- This case highlights a rare manifestation of C. parvum infection in a liver transplant setting.
Implications:
- This case expands the understanding of C. parvum's potential complications in transplant recipients.
- It underscores the importance of considering opportunistic infections in the differential diagnosis of liver dysfunction post-transplant.
- Effective treatment regimens involving azithromycin and paromomycin can be utilized for Cryptosporidium-associated cholangitis.
