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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Related Experiment Video

Updated: Jul 14, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
11:54

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Published on: July 13, 2019

Immunosuppression reduction for BK virus nephropathy: a case for caution.

K L Womer1, G Guerra, K Dibadj

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. kwomer1@jhmi.edu

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|July 4, 2007
PubMed
Summary

Reducing immunosuppression for BK virus nephropathy (BKVN) may risk acute rejection, especially in high-risk transplant centers. Careful immune monitoring is crucial to balance infection and rejection risks in renal transplant patients.

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Last Updated: Jul 14, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
11:54

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07:13

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Published on: April 12, 2021

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Virology

Background:

  • BK virus nephropathy (BKVN) is a significant cause of renal allograft loss.
  • Reducing immunosuppression upon detecting viremia may resolve BKV infections with low acute rejection (AR) risk.
  • This strategy's risk-benefit may differ in centers with high baseline AR rates.

Observation:

  • A case of antibody-mediated rejection occurred after immunosuppression reduction for BKVN.
  • BKVN was diagnosed over 3 months post-viremia onset.
  • The subsequent rejection episode caused greater graft function decline than BKVN.

Findings:

  • Reducing immunosuppression for BKVN in high-risk centers may increase AR risk.
  • Delayed BKVN diagnosis complicates management decisions.
  • The balance between managing viral infection and preventing rejection is delicate.

Implications:

  • Centers with high AR risk require tailored immunosuppression strategies for BKVN.
  • Improved immune monitoring assays are needed to guide BKVN management.
  • Optimizing immunosuppression is key to preserving renal allograft function post-transplant.