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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

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Related Experiment Video

Updated: Jul 14, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

[Bioinformatics scan analysis for predicting drug targeted modulation on ID4 gene expression].

Xue-Chun Lu1, Xiao-Hua Chi, Fang-Ding Lou

  • 1Department of Geriatric Hematology, Department of Hematolody, PLA General Hospital, Beijing 100853, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|July 4, 2007
PubMed
Summary

Investigating the ID4 gene promoter revealed potential drug targets for leukemia treatment. Identifying cis-acting elements and regulatory factors provides a foundation for developing novel ID4 expression-modulating therapies.

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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
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Published on: October 3, 2025

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Last Updated: Jul 14, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

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Published on: March 30, 2019

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Area of Science:

  • Genetics and Molecular Biology
  • Bioinformatics
  • Cancer Research

Context:

  • The ID4 gene's expression levels are linked to cancer development and leukemia progression.
  • Understanding ID4 gene regulation is crucial for developing targeted leukemia therapies.

Purpose:

  • To analyze the ID4 gene promoter structure and predict cis-acting elements using bioinformatics.
  • To identify potential drug candidates that modulate ID4 expression for leukemia treatment.

Summary:

  • Bioinformatic analysis of the ID4 5'-untranslated region identified a Type II promoter with a TATA box.
  • Numerous positive (Sp1, c-Myb, GR, ER) and negative (CCAAT-binding factor, WT1-KTS) cis-acting elements were predicted.
  • Hormones like estrogen, dexamethasone, and thyroid hormone may regulate ID4 expression.

Impact:

  • This study provides a foundational understanding of ID4 gene regulation.
  • Identified cis-elements and potential regulatory factors serve as targets for novel leukemia therapies.
  • The findings pave the way for developing drugs that leverage ID4 expression for anti-leukemia effects.