Related Experiment Video
Updated: Jul 14, 2026
04:40
Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
[Thrombin and tumor metastasis - review]
Yu-Hong Meng1, Ji-Yao Yu, Ying-Lin Lu
1Department of Pathology, Navy General Hospital of PLA, Beijing 100037, China. bjmengyh@yahoo.com.cn
Zhongguo Shi Yan Xue Ye Xue Za Zhi
|July 4, 2007
Summary
Thrombin, a serine protease, influences hemostasis, inflammation, and tissue repair. It also promotes tumor growth and metastasis by activating oncogenic pathways and remodeling the tumor microenvironment.
Area of Science:
- Biochemistry
- Cell Biology
- Oncology
Context:
- Thrombin is a serine protease with diverse roles beyond coagulation.
- It significantly impacts physiological processes like inflammation and tissue repair.
- Emerging evidence highlights thrombin's role in cancer progression.
Purpose:
- To review the multifaceted biological functions of thrombin.
- To explore the intricate relationship between thrombin and tumor development.
- To discuss the role of thrombin receptors, such as PARs, in mediating these effects.
Summary:
- Thrombin exhibits dual effects on tumor cells, promoting proliferation at low concentrations and inducing apoptosis at higher concentrations.
- It enhances tumor cell growth, invasion, angiogenesis, and metastasis through interactions with G-protein-coupled receptors (PARs).
- The review covers thrombin's physiological activities and its pathological involvement in oncogenesis.
Impact:
- Provides a comprehensive overview of thrombin's biological significance.
- Highlights thrombin as a potential therapeutic target in cancer treatment.
- Enhances understanding of molecular mechanisms driving tumor progression and metastasis.
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