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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Jul 14, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Patient Derived Cell Culture and Isolation of CD133⁺ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

Cytoreductive surgery for melanoma.

James M McLoughlin¹, Jonathan S Zager, Vernon K Sondak

¹Division of Surgical Oncology, Department of Surgey, Medical College of Georgia, Augusta, GA 30912, USA.

Surgical Oncology Clinics of North America

|July 4, 2007

Summary

Cytoreductive surgery aims to reduce tumor burden for better treatment outcomes. However, current evidence does not support its use in metastatic melanoma outside of clinical trials.

Area of Science:

Oncology
Surgical Oncology
Melanoma Research

Background:

Cytoreductive surgery attempts to reduce tumor burden to enhance postsurgical therapy effectiveness.
Palliative and curative surgery play roles in managing melanoma spread beyond regional nodes or in-transit recurrence.

Purpose of the Study:

To evaluate the efficacy and role of cytoreductive surgery in the management of metastatic melanoma.
To determine if cytoreductive surgery offers meaningful benefits to patients with metastatic melanoma.

Main Methods:

Review of existing evidence and clinical trial data regarding cytoreductive surgery for melanoma.
Comparison of cytoreductive surgery intent with palliative and curative surgical approaches.

Main Results:

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No current evidence demonstrates a meaningful benefit of cytoreductive surgery for patients with metastatic melanoma.
Cytoreductive surgery is not indicated for melanoma outside of a clinical trial setting.

Conclusions:

Cytoreductive surgery currently lacks evidence of efficacy in metastatic melanoma.
Adjuvant therapies, including vaccine therapy, have not shown efficacy after complete resection of metastatic melanoma, suggesting limited benefit after incomplete resections.