Related Experiment Video
Updated: Jul 14, 2026
06:45
Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Deep venous thrombosis associated with osteomyelitis in children
S Tyler Hollmig1, Lawson A B Copley, Richard H Browne
1Children's Medical Center Dallas, Texas Scottish Rite Hospital for Children, and University of Texas Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390-9030, USA. tyler.hollmig@utsouthwestern.edu
Summary
Deep venous thrombosis (DVT) in children with osteomyelitis is linked to Staphylococcus aureus infections, particularly methicillin-resistant strains. Early diagnosis and imaging are crucial for at-risk pediatric patients.
Area of Science:
- Pediatric Infectious Diseases
- Pediatric Thrombosis
- Musculoskeletal Infections
Background:
- Deep venous thrombosis (DVT) is infrequently reported in children with deep musculoskeletal infections.
- Osteomyelitis is a common deep musculoskeletal infection in children.
Purpose of the Study:
- To evaluate the characteristics of children with osteomyelitis who developed DVT.
- To compare these children with those who had osteomyelitis but no DVT.
Main Methods:
- Retrospective review of 212 children with osteomyelitis (January 2002-December 2004).
- Comparison of children with and without DVT based on age, diagnosis, organism, symptom duration, lab values, surgery, and hospitalization length.
Main Results:
- Eleven children with osteomyelitis and DVT were identified.
- Elevated C-reactive protein (>6 mg/dL), Staphylococcus aureus (especially MRSA), older age, longer hospitalization, ICU admission, and more surgeries were associated with DVT.
- Mean CRP was 16.9 mg/dL in the DVT group vs. 6.8 mg/dL in the non-DVT group (p=0.0044).
Conclusions:
- DVT in pediatric osteomyelitis is more common in children >8 years with MRSA infection and CRP >6 mg/dL.
- Diagnostic venous imaging is recommended for children with osteomyelitis, especially those with identified risk factors.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
01:30Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
01:27Pulmonary Embolism III: Nursing Management
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...