Related Experiment Video
Updated: Jul 14, 2026
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
A timing-of-birth effect on multiple sclerosis clinical phenotype
A D Sadovnick1, P Duquette, B Herrera
1Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. sadovnik@infinet.net
Background:
A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS).
Methods:
Our chi(2) analyses looked at whether this MOB effect differed by MS phenotype ("bout onset," "primary progressive").
Results:
The MOB effect was derived from "bout onset" MS patients (May/November ratio = 1.43; chi(2) = 17.32, df = 1, p = 0.000032).
Conclusions:
An unspecified environmental effect in early development can influence both multiple sclerosis susceptibility and phenotype.
