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Centrosome replication in hydroxyurea-arrested CHO cells expressing GFP-tagged centrin2

Ryoko Kuriyama1, Yasuhiko Terada, Kyung S Lee

  • 1Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. kuriy001@umn.edu

Journal of Cell Science
|July 4, 2007
PubMed
Summary

Hydroxyurea (HU) treatment causes abnormal centrosome duplication in Chinese hamster ovary cells by uncoupling the cell cycle. This leads to the formation of new, mobile centrosomes from cytoplasmic foci, resulting in heterogeneous centrosome numbers.

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