Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene-air pollution interactions in asthma.

Stephanie J London1

  • 1Epidemiology Branch and Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. London2@niehs.nih.gov

Proceedings of the American Thoracic Society
|July 4, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood.

Environmental health perspectives·2026
Same author

Publisher Correction: Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants.

Genome biology·2026
Same author

Smoking drives an epigenetic memory of aberrant hematopoiesis.

medRxiv : the preprint server for health sciences·2026
Same author

Pipe and cigar use, lung function decline and clinical outcomes: an analysis of the NHLBI Pooled Cohorts Study.

Thorax·2026
Same author

Proteomic Profiling of Pulmonary Function and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study.

Journal of the American Heart Association·2026
Same author

Circulating proteomic landscape of lung function.

The European respiratory journal·2026

Asthma arises from gene-environment interactions, but these are understudied. Key genes like GSTM1 and TNF may influence respiratory responses to environmental tobacco smoke and ozone.

Area of Science:

  • Environmental health
  • Genetics
  • Respiratory medicine

Background:

  • Asthma development is influenced by both genetic predisposition and environmental exposures.
  • Current research often isolates genetic or environmental factors, limiting understanding of their interplay.
  • Specific gene-environment interactions in asthma etiology remain underexplored.

Purpose of the Study:

  • To review existing literature on gene-environment interactions in asthma.
  • To highlight specific gene interactions with environmental tobacco smoke and ozone.
  • To identify knowledge gaps and suggest future research directions.

Main Methods:

  • Literature review focusing on gene-environment interactions in asthma.
  • Analysis of studies examining genetic influences on responses to inhaled pollutants.

Related Experiment Videos

  • Synthesis of evidence for specific genes (GSTM1, TNF) and pollutant interactions.

    • Main Results:

    • Few documented examples of gene-environment interactions in asthma.
    • Evidence suggests GSTM1 and TNF gene variants may mediate respiratory effects of ozone and environmental tobacco smoke.
    • Limited data exists on innate immune genes' roles in response to these pollutants.

    Conclusions:

    • Gene-environment interactions are critical for understanding asthma.
    • Genes involved in oxidative stress may interact with air pollutants and diet.
    • Future research requires integrated approaches, including genomics and detailed exposure/phenotype assessment.