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Updated: Jul 14, 2026

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

Ozone and pulmonary innate immunity.

John W Hollingsworth¹, Steven R Kleeberger, W Michael Foster

¹Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Box 3136, Durham, NC 27710, USA. holli017@mc.duke.edu

Proceedings of the American Thoracic Society

|July 4, 2007

Summary

Ambient ozone (O(3)) impairs the lungs' first defense, the innate immune system. This common air pollutant disrupts the epithelial barrier and pathogen-clearing functions, weakening antibacterial defenses.

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Area of Science:

Environmental Health
Immunology
Toxicology

Background:

Ambient ozone (O(3)) is a widespread air pollutant affecting public health.
Inhaled environmental toxicants can significantly alter pulmonary immune responses.
Understanding irritant-immune interactions is crucial for managing environmentally linked diseases.

Purpose of the Study:

To review the intricate relationship between ozone inhalation and pulmonary innate immunity.
To highlight the impact of ubiquitous air toxins on fundamental immune functions.
To use ambient ozone as a model for studying air toxin and immune system interactions.

Main Methods:

Literature review focusing on the effects of ambient ozone on pulmonary immune responses.
Analysis of studies investigating the mechanisms of ozone-induced immune dysfunction.
Synthesis of data on the role of innate immunity components in ozone exposure.

Main Results:

Ozone inhalation compromises antibacterial host defense mechanisms.
Impaired epithelial barrier function and reduced phagocytosis are key effects of ozone exposure.
The immune response to ozone is modulated by various innate immune signaling pathways.

Conclusions:

Ambient ozone exposure significantly impacts pulmonary innate immunity.
Disruption of immune functions by ozone can lead to increased susceptibility to infections.
Further research is needed to fully elucidate the complex interplay between air pollutants and immune health.