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No association between TGFBR1*6A and lung cancer
Weiming You1, Zeyi Liu, Jun Zhao
1Laboratory of Medical Genetics, School of Life Sciences, Suzhou University, Suzhou PR China.
Introduction:
TGFBR1*6A, a functionally polymorphic allele in the transforming growth factor [beta] receptor 1 gene (TGFBR1), has been hypothesized to increase risk of various cancers. However, little has been documented about connection of this variant with lung cancer.
Methods:
In an attempt to explore whether the TGFBR1*6A is associated with lung cancer, we performed genotyping followed by sequencing in 252 patients with lung cancer and 250 healthy controls.
Results:
The frequency for the heterozygote 9A/6A is 13.9% in cases compared with 12.4% in controls, and the odds ratio is 1.14 (95% confidence interval: 0.68-1.91), which is not statistically significant (p = 0.62), suggesting that TGFBR1*6A could not be a cancer susceptibility factor for Chinese patients with lung cancer.
Conclusions:
We have no evidence to support the hypothesis that TGFBR1*6A is associated with lung cancer.
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