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Temperature dependence of carbachol-induced modulation of miniature end-plate potential frequency in rats
E E Nikolsky1, E G Strunsky, F Vyskocil
1Kazan Medical Institute, Tatar Autonomic Republic, U.S.S.R.
Brain Research
|September 27, 1991
Abstract:
In the rat soleus, the frequency of miniature end-plate potentials (MEPP) did not change after application of 10(-5) M of the cholinomimetic drug carbachol between 18 degrees C and 34 degrees C but decreased by 40% at physiological temperatures of 37-38 degrees C. The carbachol-induced decrease in MEPP frequency was not eliminated by 10(-7) to 10(-8) M atropine or 3 x 10(-7) (+)-tubocurarine similarly as had been previously found at frog neuromuscular junction.
