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Bridging the Bio-Electronic Interface with Biofabrication
Published on: June 6, 2012
A novel method for producing electron transparent films of interfaces between cells and biomaterials
Håkan Engqvist1, Fredrik Svahn, Tobias Jarmar
1Department of Materials Science, Angstrom Laboratory, Uppsala University, Box 534, 751 21 Uppsala, Sweden. hakan.engqvist@angstrom.uu.se
Journal of Materials Science. Materials in Medicine
|July 4, 2007
Abstract:
Transmission electron microscopy (TEM) investigations of intact interfaces of cells and brittle biomaterials have proven difficult using common TEM preparation techniques. This paper describes a technique to fabricate thin sections for TEM investigation of intact interfaces between human monocytes and sintered hydroxylapatite by the use of focused ion beam (FIB) microscopy. The interfaces were examined using energy filtered TEM.
