Related Experiment Video

Updated: Jul 14, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

Many faces of NF-kappaB signaling induced by genotoxic stress

Zhao-Hui Wu1, Shigeki Miyamoto

  • 1Department of Pharmacology, University of Wisconsin-Madison, WI 53706, USA.

Journal of Molecular Medicine (Berlin, Germany)
|July 4, 2007
PubMed

Insights

Nuclear factor-kappaB (NF-kappaB) activation by DNA-damaging agents is crucial for cancer treatment. This review summarizes proposed mechanisms and highlights key questions for future research on NF-kappaB signaling in cancer.

Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Oncology

Background:

  • Nuclear factor-kappaB (NF-kappaB) is a transcription factor family involved in immune responses, inflammation, and cancer.
  • NF-kappaB typically resides in the cytoplasm bound to inhibitor of NF-kappaB (IkappaB) proteins.
  • Activation requires release from IkappaB, nuclear translocation, and target gene expression.

Purpose of the Study:

  • To review mechanisms of NF-kappaB activation by DNA-damaging agents.
  • To discuss the significance of this activation in cancer treatment.
  • To identify critical unanswered questions in the field.

Main Methods:

  • Literature review of proposed NF-kappaB activation pathways by DNA-damaging agents.
  • Synthesis of current understanding of NF-kappaB signaling in cancer therapy.
  • Identification of knowledge gaps and future research directions.

Main Results:

  • Multiple, often conflicting, pathways mediate NF-kappaB activation by DNA damage.
  • NF-kappaB activation by DNA-damaging agents has significant implications for cancer treatment efficacy.
  • The precise mechanisms and their therapeutic relevance require further elucidation.

Conclusions:

  • Understanding NF-kappaB activation by DNA damage is critical for optimizing cancer therapies.
  • Further research is needed to resolve conflicting pathways and harness NF-kappaB signaling for improved cancer treatment outcomes.

More Related Videos

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor09:33

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...