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Updated: Jul 14, 2026
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Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
Protein arrays for biomarker discovery.
Jennifer D Reid1, Carol E Parker, Christoph H Borchers
1University of Victoria Genome BC Proteomics Centre, Vancouver Island Technology Park, 3101-4464 Markham Street, Victoria, BC V8Z 7X8, Canada.
Current Opinion in Molecular Therapeutics
|July 5, 2007
Summary
Biomarker research advances diagnostic and predictive medicine. This review covers high-throughput protein microarrays and mass spectrometry for accurate clinical biomarker discovery.
Area of Science:
- Biomarker research
- Diagnostics
- Predictive medicine
Background:
- Diagnostic tests have evolved from single-molecule monitoring to multiplexed assays.
- Comprehensive biomarker data aids clinicians in effective patient treatment.
- Protein microarrays are key for high-throughput, quantitative biomarker analysis.
Purpose of the Study:
- To review advancements in biomarker discovery techniques.
- To discuss high-throughput multiplex assays for clinical applications.
- To evaluate mass spectrometry-based approaches in biomarker research.
Main Methods:
- Review of current literature on protein microarrays.
- Analysis of mass spectrometry-based biomarker discovery techniques.
- Discussion of assay development for clinical laboratory requirements.
Main Results:
- Protein microarrays enable high-throughput, quantitative biomarker data.
- Advancements include mass spectrometry-based approaches.
- Various techniques offer different advantages and limitations.
Conclusions:
- High-throughput multiplex assays are crucial for clinical diagnostics.
- Accurate quantitative data from protein microarrays meets clinical needs.
- Continued research in biomarker discovery is essential for personalized medicine.
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