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Updated: Jul 14, 2026

Development of an In Vitro Ocular Platform to Test Contact Lenses
Published on: April 6, 2016
[Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum]
Guo-hua Wang1, Qi-xia Nie, Hui Li
1Institute of Chinese Materia Medica, China Academy of CMS, Beijing 100700, China.
Objective:
To prepare tuizhang gel to cure cataract, the characteristics of Tuizhang gel on the drug-releasing in vitro were evaluated by compared with Tuizhang oculentum.
Method:
The emodin and chrysophanol in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Tuizhang gel and Tuizhang oculentum were studied by bag filter method.
Result:
The emodin and chrysophanol in Tuizhang gel released (98.3, 1.1)%, (95.8, 1.8)% within 24 hours, respectively, while those in tuizhang oculentum released (10.62, 0.7)%, (10.46, 0.4)%, respectively. The emodin and chrysophanol in Tuizhang gel released more quickly and completely than in Tuizhang oculentum, so Tuizhang gel has enhanced the bioavailability.
Conclusion:
The Tuizhang gel is characterized by slow-release to some degree, and it shows a promising future on ophthalmic drug delivery.
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