Power calculation for case-cohort studies with nonrare events
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Updated: Jun 10, 2026

Inverse Probability of Treatment Weighting (Propensity Score) using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
1Department of Biostatistics, University of North Carolina at Chapel Hill, North Carolina 27599-7420, USA.
Abstract:
Case-cohort design has been advocated in many epidemiologic studies when studying rare diseases or events. In this design, with a rare event, all the events are selected for risk-factor assessment. When the event is not rare, it is desirable to consider a generalized case-cohort design, where only a fraction of events are sampled. We provide a valid test statistic to compare hazards functions between two samples for this generalized design and give a method for calculating power. Our result generalizes the result in Cai and Zeng (2004, Biometrics60, 1015-1024), and it shows numerically that efficiency loss due to sampling only part of the events is very low under nonrare-events situation.
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