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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

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Published on: January 29, 2018

Mortality and GH deficiency: a nationwide study.

Kirstine Stochholm¹, Claus Højbjerg Gravholt, Torben Laursen

¹Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus, NBG, DK-8000 Aarhus C, Denmark. stochholm@dadlnet.dk

European Journal of Endocrinology

|July 5, 2007

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Patients with growth hormone deficiency (GHD) have increased mortality. This risk is higher in childhood-onset GHD and adult-onset GHD females compared to males, with cancer and circulatory diseases being key causes.

Area of Science:

Endocrinology
Public Health
Epidemiology

Background:

Growth hormone deficiency (GHD) is a complex endocrine disorder.
Understanding GHD's impact on long-term mortality is crucial for patient management.

Purpose of the Study:

To estimate all-cause mortality in Danish patients with GHD.
To compare mortality rates between GHD patients and matched controls.
To investigate sex- and cause-specific mortality in childhood-onset (CO) and adult-onset (AO) GHD.

Main Methods:

Retrospective analysis of 1794 GHD patients and 8014 matched controls in Denmark.
GHD patients categorized into CO (onset <18 years) and AO (onset >18 years).
Mortality data sourced from national registries; cause-specific mortality analyzed.

Related Experiment Videos

Last Updated: Jul 13, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Main Results:

Significantly increased mortality observed in both CO and AO GHD patients across both genders compared to controls.
Hazard ratios (HR) for CO GHD: males 8.3, females 9.4. For AO GHD: males 1.9, females 3.4.
AO females exhibited higher mortality than AO males. Increased mortality linked to cancer and circulatory diseases in AO GHD, and cancer in CO GHD.

Conclusions:

GHD is associated with significantly elevated mortality, potentially linked to hypopituitarism.
Adult-onset GHD females face higher mortality risks than males.
Distinct causes contribute to increased mortality in CO and AO GHD.