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Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Production of Formed Elements01:34

Production of Formed Elements

Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

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Related Experiment Video

Updated: Jul 13, 2026

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow
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Human circulating monocytes as multipotential progenitors.

Noriyuki Seta1, Masataka Kuwana

  • 1Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.

The Keio Journal of Medicine
|July 5, 2007
PubMed
Summary

Circulating monocytes are more versatile than previously thought, generating novel monocyte-derived multipotential cells (MOMC). These MOMC can differentiate into various non-phagocytic cell types, suggesting potential for tissue regeneration therapies.

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Published on: August 9, 2019

Area of Science:

  • Cell Biology
  • Regenerative Medicine
  • Hematology

Background:

  • Circulating monocytes are traditionally considered precursors to phagocytes like macrophages and dendritic cells.
  • Recent research has identified a novel primitive human cell population, monocyte-derived multipotential cells (MOMC).

Purpose of the Study:

  • To characterize the novel monocyte-derived multipotential cells (MOMC) and their differentiation potential.
  • To investigate the role of circulating monocytes in generating multipotential progenitor cells.

Main Methods:

  • Isolation and characterization of monocyte-derived multipotential cells (MOMC) from human peripheral blood.
  • Analysis of MOMC phenotype (CD14, CD45, CD34, type I collagen) and morphology.
  • Assessment of MOMC differentiation capacity into various non-phagocytic cell lineages.

Main Results:

  • Monocyte-derived multipotential cells (MOMC) exhibit a fibroblast-like morphology and a unique phenotype.
  • MOMC are derived from CD14+ monocytes and require fibronectin binding and soluble factors for differentiation.
  • MOMC contain progenitors capable of differentiating into bone, cartilage, fat, muscle, neuron, and endothelial cells.

Conclusions:

  • Circulating monocytes possess greater multipotentiality than previously recognized.
  • Monocyte-derived multipotential cells (MOMC) represent a promising cell source for tissue regeneration and cell transplantation therapies.