Related Experiment Video
Updated: Jan 10, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Severe methotrexate toxicity precipitated by intravenous radiographic contrast
Theresa M Harned1, Leo Mascarenhas
1Division of Hematology/Oncology, Childrens Hospital Los Angeles, CA 90027, USA.
Abstract:
Methotrexate (MTX), a widely used anticancer agent, and intravenous iodinated contrast used for radiographic studies can both cause acute renal failure. Their combined exposure may place patients at higher risk for renal failure. This report describes 2 pediatric patients with MTX toxicity precipitated by the use of intravenous radiographic contrast. One patient recovered with leucovorin rescue therapy, whereas the second patient responded to carboxypeptidase-G2. Both patients suffered MTX-related toxicities including myelosuppression and mucositis, but recovered full renal function and tolerated further high-dose MTX therapy. These cases suggest that intravenous iodinated contrast should be avoided in patients receiving high-dose MTX.
Related Concept Videos
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Imaging Studies VII: Vascular Imaging
Imaging Studies III: Computed Tomography
Imaging Studies for Cardiovascular System V: CT
Radiological Investigation I: X-ray and CT
Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...

