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COX2 genetic variation, NSAIDs, and advanced prostate cancer risk

I Cheng1, X Liu, S J Plummer

  • 1Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143-0794, USA.

British Journal of Cancer
|July 5, 2007
PubMed

Insights

Genetic variations in cyclooxygenase 2 (COX2) may influence advanced prostate cancer risk. One specific COX2 polymorphism (rs2745557) showed a notable association with reduced disease risk in a case-control study.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Cyclooxygenase 2 (COX2) is implicated in prostate cancer development.
  • Prostaglandins, produced by COX2, are key inflammatory mediators.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit COX2 and may reduce prostate cancer risk.

Purpose of the Study:

  • To investigate the association between common genetic variations in COX2 and the risk of advanced prostate cancer.
  • To explore potential gene-environment interactions between COX2 polymorphisms and NSAID use.

Main Methods:

  • A case-control study involving 1012 men with advanced prostate cancer.
  • Genotyping of nine single-nucleotide polymorphisms (SNPs) in the COX2 gene.
  • Collection of NSAID use data via questionnaire.

Main Results:

  • Three COX2 SNPs showed nominal associations with prostate cancer risk.
  • The rs2745557 polymorphism was significantly associated with a lower risk of advanced prostate cancer (OR=0.64).
  • NSAID use was independently associated with a reduced risk of prostate cancer (OR=0.67).

Conclusions:

  • Genetic variation in COX2 appears to be associated with prostate cancer risk.
  • While NSAID use showed a protective effect, no significant interaction with the rs2745557 polymorphism was detected.

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