Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transient Ischemic Attack l: Introduction

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Technostress in older healthcare workers: Latent profiles and implications for care robot acceptance.

Digital health·2026

Same author

Unveiling topic dependencies through a multilevel topic model: a hierarchical approach to enhanced interpretability.

Journal of applied statistics·2026

Same author

Clinical Efficacy and Tolerability of Sorafenib in Dogs With Advanced Carcinomas.

Veterinary and comparative oncology·2026

Same author

Dihydroartemisinin inhibits metastatic potential and cancer stemness by modulating the miR-200b-BMI-1/VEGF-A axis in ovarian cancer.

Experimental & molecular medicine·2025

Same author

Enhancing Ferroptosis in Lung Adenocarcinoma Cells via the Synergistic Action of Nonthermal Biocompatible Plasma and a Bioactive Phenolic Compound.

Biomolecules·2025

Same author

Surface-engineered nanobeads for regioselective antibody binding: A robust immunoassay platform leveraging catalytic signal amplification.

Biosensors & bioelectronics·2025

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Stage transition duration in patients poststroke.

Youngsun Kim¹, Gary H McCullough

¹School of Hearing, Speech and Language Sciences, College of Health and Human Services, Ohio University, Athens, Ohio 45701-2979, USA. kimy2@ohio.edu

|July 5, 2007

Summary

Prolonged stage transition duration (STD) is linked to aspiration in stroke survivors. This finding helps predict aspiration risk, aiding in patient care and management.

Area of Science:

* Clinical Swallowing and Deglutition Disorders
* Neurology and Stroke Rehabilitation

Background:

* Aspiration, the entry of foreign material into the airway, is a significant complication following stroke.
* Understanding predictors of aspiration is crucial for effective patient management and preventing associated morbidities like pneumonia.

Purpose of the Study:

* To investigate the relationship between prolonged stage transition duration (STD) and the presence of aspiration in stroke patients.
* To determine if STD can serve as a predictive marker for aspiration post-stroke.

Main Methods:

* Retrospective analysis of videofluoroscopic swallowing studies (VFSS) from stroke patients and normal subjects.
* Measurement of stage transition duration (STD) and aspiration ratings from existing VFSS data.

More Related Videos

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

Related Experiment Videos

Last Updated: Jul 13, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

* Comparison of STD in three groups: stroke patients who aspirate, stroke patients who do not aspirate, and healthy controls.

Main Results:

* Stroke patients who aspirated exhibited significantly longer stage transition durations (STD) compared to non-aspirating stroke patients and normal subjects.
* STD demonstrated a 75% accuracy in predicting the presence of aspiration.
* STD showed a 93% accuracy in predicting the absence of aspiration in stroke patients, with non-aspirating patients showing similar patterns to controls.

Conclusions:

* Prolonged stage transition duration is a reliable indicator associated with aspiration in the stroke population.
* STD measurement from VFSS can be a valuable tool for identifying stroke patients at risk of aspiration.
* Findings suggest potential for incorporating STD analysis into routine dysphagia screening protocols for stroke survivors.