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A Choroid Plexus Epithelial Cell-based Model of the Human Blood-Cerebrospinal Fluid Barrier to Study Bacterial Infection from the Basolateral Side
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Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in

J Bishara1, N Hadari, M Shalita-Chesner

  • 1Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. bishara@netvision.net.il

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|July 5, 2007
PubMed

Insights

Soluble triggering receptor expressed on myeloid cells (sTREM-1) is elevated in cerebrospinal fluid during bacterial meningitis. This biomarker shows high specificity and can aid in diagnosing bacterial meningitis.

Area of Science:

  • Neuroscience
  • Immunology
  • Infectious Diseases

Background:

  • Meningitis is a serious infection of the membranes surrounding the brain and spinal cord.
  • Accurate and rapid diagnosis is crucial for effective treatment and patient outcomes.
  • Biomarkers are needed to differentiate bacterial from other causes of meningitis.

Purpose of the Study:

  • To investigate the presence and diagnostic value of soluble triggering receptor expressed on myeloid cells (sTREM-1) in cerebrospinal fluid (CSF).
  • To determine if sTREM-1 levels can predict bacterial meningitis.

Main Methods:

  • Cerebrospinal fluid (CSF) samples were collected from patients with acute meningitis.
  • Levels of sTREM-1 were measured in the CSF.
  • CSF samples were analyzed for bacterial culture to confirm infection.
  • Receiver operating characteristic (ROC) curve analysis was performed to assess diagnostic accuracy.

Main Results:

  • Elevated sTREM-1 levels were detected in 78% of patients with culture-positive bacterial meningitis.
  • sTREM-1 was not detected in culture-negative meningitis cases (0% detection).
  • The sensitivity for bacterial meningitis was 78%, with a specificity of 100%.

Conclusions:

  • sTREM-1 is significantly upregulated in the CSF of patients with bacterial meningitis.
  • sTREM-1 demonstrates high specificity as a biomarker for bacterial meningitis.
  • Measuring CSF sTREM-1 levels may assist clinicians in the rapid diagnosis of bacterial meningitis.

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