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Retrospective economic and outcomes analyses using non-US databases: a review.
Lizheng Shi1, Eric Q Wu, Meredith Hodges
1Department of Health Systems Management, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA. lshi1@tulane.edu
Pharmacoeconomics
|July 6, 2007
Summary
Conducting retrospective database studies outside the US presents unique methodological challenges. Improving the quality of these economic and outcomes research studies requires adherence to established checklists for better validity.
Area of Science:
- * Health Economics
- * Outcomes Research
- * Data Science
Background:
- * Retrospective database analyses face methodological hurdles, especially with non-US data sources.
- * Existing research highlights variations in study quality and data limitations.
Purpose of the Study:
- * To qualitatively review methodological challenges in retrospective economic and outcomes research using non-US databases.
- * To identify common issues in data sources, methods, and validity threats.
Main Methods:
- * A MEDLINE search identified relevant literature published after 2000.
- * Articles were reviewed against the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) checklist.
- * Issues related to data sources, methods, statistics, and validity were cataloged.
Main Results:
- * Significant variation exists in study quality regarding outcome definitions, patient selection, and data collection.
- * Challenges include small sample sizes, inadequate risk adjustment, measurement errors, and limited external validity.
- * Economic studies often lacked indirect cost data due to insufficient information.
Conclusions:
- * The quality of retrospective database analyses using non-US data is variable.
- * Implementing the ISPOR Task Force checklist can enhance the rigor and reliability of future studies.
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