Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C. elegans aging: proteolysis cuts both ways.

Bruce Bowerman1

  • 1Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA. bbowerman@molbio.uoregon.edu

Current Biology : CB
|July 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II.

The Journal of cell biology·2026
Same author

Anaphase onset requires CKS-1-mediated destruction of securin in meiosis I and cyclin B1 in meiosis II.

The Journal of cell biology·2026
Same author

Distinct requirements for the C. elegans Delta ligand APX-1 in embryonic viability and adult fertility.

G3 (Bethesda, Md.)·2025
Same author

Microtubules oppose cortical actomyosin-driven membrane ingression during C. elegans meiosis I polar body extrusion.

PLoS genetics·2023
Same author

Cortical microtubules oppose actomyosin-driven membrane ingression during

bioRxiv : the preprint server for biology·2023
Same author

C. elegans XMAP215/ZYG-9 and TACC/TAC-1 act at multiple times during oocyte meiotic spindle assembly and promote both spindle pole coalescence and stability.

PLoS genetics·2023
Same journal

Proprioceptive cortical neurons implement optimal state estimation.

Current biology : CB·2026
Same journal

Coumarins link iron deficiency to TOR inhibition in plants.

Current biology : CB·2026
Same journal

Space-based monitoring of penguin diet links sea ice, food webs, and population change.

Current biology : CB·2026
Same journal

A global response contributes to tissue size robustness upon local induction of apoptosis.

Current biology : CB·2026
Same journal

Prebilaterian origin of monoaminergic signaling.

Current biology : CB·2026
Same journal

CLASP-dependent microtubule stabilization generates microtubule-based protrusive forces during Drosophila epithelial morphogenesis.

Current biology : CB·2026
See all related articles

Ubiquitin-mediated proteolysis plays dual roles in regulating lifespan by the insulin/insulin-like growth factor signaling pathway in the nematode Caenorhabditis elegans.

Area of Science:

  • Molecular Biology
  • Genetics
  • Aging Research

Background:

  • The insulin/insulin-like growth factor (IGF) signaling pathway is a key regulator of aging and longevity across many species.
  • Ubiquitin-mediated proteolysis is a critical cellular process involved in protein degradation and cellular homeostasis.

Purpose of the Study:

  • To investigate the specific roles of ubiquitin-mediated proteolysis in the context of insulin/IGF signaling and its impact on longevity.
  • To elucidate the mechanisms by which protein degradation influences lifespan regulation.

Main Methods:

  • Studies were conducted using the model organism Caenorhabditis elegans.
  • Analysis involved genetic and molecular approaches to assess the function of ubiquitin-mediated proteolysis components within the insulin/IGF signaling pathway.

Related Experiment Videos

Main Results:

  • Reports indicate that ubiquitin-mediated proteolysis can have both positive and negative effects on longevity.
  • Specific components of this degradation pathway modulate the activity or levels of key insulin/IGF signaling molecules, thereby influencing lifespan.

Conclusions:

  • Ubiquitin-mediated proteolysis is an integral and complex regulator of longevity, acting through the insulin/IGF signaling pathway.
  • Understanding these dual roles is crucial for deciphering the intricate mechanisms of aging and developing potential interventions.