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Updated: Jul 13, 2026
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"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
[Hepatitis B and liver transplantation].
Imre Fehérvári1, Dénes Görög, László Kóbori
1Semmelweis Egyetem, Altalános Orvostudományi Kar Transzplantációs és Sebészeti Klinika, Budapest, Hungary. fehervar@trans.sote.hu
Orvosi Hetilap
|July 6, 2007
Summary
Liver transplantation outcomes for Hepatitis B Virus (HBV) patients in Hungary show 75% survival. However, de novo HBV infections occurred in 6 transplant recipients, highlighting ongoing challenges.
Area of Science:
- Hepatology
- Transplant Surgery
- Virology
Background:
- Hepatitis B Virus (HBV) infection is a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide.
- Liver transplantation is a definitive treatment for end-stage liver disease caused by HBV.
- Managing HBV patients undergoing liver transplantation requires specialized pre- and postoperative care.
Observation:
- This study reviews liver transplantation outcomes for HBV patients in Hungary.
- Four patients underwent liver transplantation due to HBV-related cirrhosis.
- The study also examines the incidence of de novo HBV infections post-transplantation.
Findings:
- Three out of four (75%) liver transplant recipients with HBV are alive and active post-surgery.
- One patient experienced early postoperative mortality.
- Six cases of de novo HBV infections were identified in transplanted patients.
Implications:
- Liver transplantation can be successful for select HBV patients, offering improved survival and quality of life.
- The occurrence of de novo HBV infections necessitates vigilant monitoring and potentially enhanced prophylactic strategies.
- Further research is needed to optimize immunosuppression protocols and antiviral therapies to prevent de novo HBV infections in liver transplant recipients.
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