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Updated: Jul 13, 2026
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Notch signaling in vascular development and physiology
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. tom.gridley@jax.org
Development (Cambridge, England)
|July 6, 2007
Summary
Notch signaling regulates blood vessel development and function. Modulating this pathway offers promising therapeutic strategies for vascular and cardiovascular diseases.
Area of Science:
- Vascular Biology
- Cell Signaling
- Developmental Biology
Background:
- Notch signaling is a conserved intercellular mechanism vital for vertebrate vascular development and physiology.
- It controls artery/vein differentiation, blood vessel sprouting, branching in development and angiogenesis, and vascular smooth muscle cell function.
- Dysregulation of Notch signaling is implicated in inherited vascular and cardiovascular diseases.
Purpose of the Study:
- To review recent findings on Notch signaling in vascular biology.
- To discuss the therapeutic potential of modulating the Notch pathway for treating diseases.
Main Methods:
- Literature review of recent research on Notch signaling.
- Synthesis of information regarding Notch pathway roles and therapeutic applications.
Main Results:
- Notch signaling is crucial for multiple aspects of vascular development and homeostasis.
- Recent advances highlight its involvement in angiogenesis and vascular smooth muscle cell differentiation.
- Therapeutic targeting of Notch is emerging as a viable strategy for vascular diseases.
Conclusions:
- Notch pathway modulation holds significant therapeutic promise for various vascular and cardiovascular conditions.
- Further research into Notch signaling mechanisms will likely uncover new treatment avenues.
Related Concept Videos
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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01:10Mechanism of Angiogenesis
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