Related Experiment Video

Updated: Jul 13, 2026

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
09:51

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System

Published on: January 1, 2018

Acute stress facilitates hippocampal CA1 metabotropic glutamate receptor-dependent long-term depression

Francis Chaouloff1, Agnès Hémar, Olivier Manzoni

  • 1Centre National de la Recherche Scientifique Unité Mixte de Recherche 5091 Physiologie Cellulaire de la Synapse, Institut François Magendie, 33077 Bordeaux, France. francis.chaouloff@bordeaux.inserm.fr

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 6, 2007
PubMed

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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