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[Modification of vascular risk factors by intervention on the primary care level. Results of the INVADE project]

C Schulze Horn1, K Sander, R Ilg

  • 1Neurologische Klinik TU München, Ismaningerstrasse 22, Munich, Germany. csh76@gmx.de

Der Nervenarzt
|July 6, 2007
PubMed

Insights

The INVADE project successfully reduced vascular risk factors like high blood pressure and cholesterol in patients over two years. This intervention improved cardiovascular health and identified previously undiagnosed peripheral arterial disease (PAD).

Area of Science:

  • Cardiovascular Medicine
  • Vascular Health
  • Primary Care Interventions

Background:

  • The INVADE project investigated the impact of consistent diagnosis and treatment of cerebrovascular risk factors on stroke incidence.
  • Cardiovascular risk factors are key contributors to cerebrovascular disease, peripheral arterial disease (PAD), and coronary heart disease (CHD).

Purpose of the Study:

  • To evaluate the efficacy of a two-year intervention program in managing cardiovascular risk factors.
  • To assess the impact of interventions on cerebrovascular disease, PAD, and CHD.
  • To identify asymptomatic PAD using the ankle-brachial index (ABI).

Main Methods:

  • A cohort of 2930 patients was analyzed, comparing cardiovascular risk factors and medication use at baseline and after a two-year intervention.
  • Known risk factors included elevated blood pressure, obesity (dipositas), hyperlipidemia, diabetes mellitus, and smoking.
  • The ankle-brachial index (ABI) was used to screen for peripheral arterial disease (PAD).

Main Results:

  • Asymptomatic PAD was identified in 13% (381 patients) of the study population via ABI.
  • Significant reductions were observed in elevated blood pressure, obesity, and LDL cholesterol for cerebrovascular disease.
  • Intervention led to notable decreases in elevated blood pressure, smoking, elevated cholesterol, obesity, and LDL for PAD and CHD.

Conclusions:

  • The ankle-brachial index (ABI) effectively identified previously undiagnosed asymptomatic peripheral arterial disease (PAD) in 13% of patients.
  • A two-year primary care-level intervention significantly reduced key vascular risk factors.
  • Consistent management of vascular risk factors shows promise in improving patient outcomes and preventing cardiovascular events.
Abstract

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