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Quality and effect of single dose versus split dose of polyethylene glycol bowel preparation for early-morning

J S Park1, C I Sohn, S J Hwang

  • 1Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Endoscopy
|July 6, 2007
PubMed

Insights

Split-dose polyethylene glycol bowel preparation significantly improves colonoscopy prep quality for early morning procedures. This method enhances visualization compared to the conventional single-dose approach, aiding in better diagnostic accuracy.

Area of Science:

  • Gastroenterology
  • Medical Procedures
  • Clinical Research

Background:

  • Conventional single-dose polyethylene glycol (PEG) bowel preparation before early morning colonoscopy can lead to suboptimal bowel cleansing.
  • Effective bowel preparation is crucial for accurate colonoscopy diagnosis and reducing procedure time.

Purpose of the Study:

  • To evaluate the efficacy of a split-dose versus a conventional single-dose regimen of PEG solution for early morning colonoscopy.
  • To compare the quality of bowel preparation, cecal intubation time, and technical difficulty between the two preparation methods.

Main Methods:

  • A randomized controlled trial involving 303 patients undergoing early morning colonoscopy.
  • Group A received 4L PEG solution the day before (single-dose).
  • Group B received 3L PEG solution the day before and 1L on the morning of colonoscopy (split-dose). Bowel preparation quality was assessed using the Ottawa scale.

Main Results:

  • No significant difference in patient compliance between the single-dose and split-dose groups.
  • The split-dose group (Group B) demonstrated significantly better bowel preparation quality compared to the single-dose group (Group A).
  • Within the split-dose group, patients with good compliance showed a significantly higher quality of bowel preparation than those with poor compliance.

Conclusions:

  • Split-dose bowel preparation using polyethylene glycol solution is superior to the conventional single-dose method for patients undergoing early morning colonoscopy.
  • This improved preparation quality facilitates better visualization during the colonoscopy procedure.
  • The split-dose regimen is recommended for optimizing bowel cleansing prior to early morning colonoscopies.
Abstract

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