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Effect of RU-38486 on dexamethasone reversal of morphine-induced constipation in mice
P Persico1, A Capasso, A Calignano
1Department of Experimental Pharmacology, University of Naples Federico II, Italy.
General Pharmacology
|January 1, 1991
Abstract:
1. Morphine and dexamethasone significantly reduce gastrointestinal transit in mice. The degree of reduction was greater for morphine. 2. Dexamethasone pretreatment was found, however, to antagonize morphine-induced constipation. 3. Cycloheximide does not modify the dexamethasone effects. 4. RU-38486 reverses both the inhibitory action of dexamethasone on gastrointestinal transit and its reducing effect on morphine-induced constipation. 5. These results suggest that dexamethasone might act through binding to receptors not linked to DNA-responsive elements.