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Related Experiment Videos

[Selenium in critically ill patients with systemic inflammatory response].

W Manzanares Castro1

  • 1Cátedra de Medicina Intensiva, Facultad de Medicina, Universidad de la República UDeLaR, Montevideo, Uruguay. wmanzanares@adinet.com.uy

Nutricion Hospitalaria
|July 7, 2007
PubMed
Summary
This summary is machine-generated.

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Selenium supplementation may benefit critically ill patients with Systemic Inflammatory Response Syndrome (SIRS) and Multiple Organ Dysfunction (MOD). While some studies show reduced complications and hospital stays, high-dose selenium has not improved mortality, necessitating further research.

Area of Science:

  • Biochemistry
  • Clinical Nutrition
  • Critical Care Medicine

Context:

  • Critically ill patients with Systemic Inflammatory Response Syndrome (SIRS) and Multiple Organ Dysfunction (MOD) face severe oxidative stress.
  • These patients often exhibit reduced levels of essential selenium and vital selenoenzymes, such as Glutathione Peroxidase and Selenoprotein P.
  • Selenoenzymes are crucial for cellular protection against lipid peroxidation and regulating inflammatory responses.

Purpose:

  • To review selenium metabolism and the function of selenoenzymes in critical illness.
  • To evaluate clinical trials on selenium supplementation in critically ill patients.
  • To analyze current parenteral selenium replacement strategies and their outcomes.

Summary:

  • Selenium deficiency in critically ill patients correlates with disease severity and mortality.

Related Experiment Videos

  • Some trials suggest selenium supplementation may reduce infectious complications and hospital stay.
  • High-dose selenium supplementation has not yet demonstrated significant mortality benefits in clinical trials.

    • Impact:

    • Findings highlight the complex role of selenium in critical illness.
    • Identifies a need for well-designed, multicenter randomized trials to clarify optimal selenium supplementation strategies.
    • Informs future research directions for improving outcomes in critically ill patients.