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Related Concept Videos

Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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Cdc20: a WD40 activator for a cell cycle degradation machine.

Hongtao Yu1

  • 1Department of Pharmacology, The University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA. hongtao.yu@utsouthwestern.edu

Molecular Cell
|July 7, 2007
PubMed
Summary

Cdc20 protein is crucial for cell division, activating the APC/C complex to degrade key proteins and allow mitosis completion. Its regulation integrates multiple cell cycle signals.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cdc20 is a vital cell-cycle regulator essential for mitosis completion in eukaryotes.
  • It contains a WD40 repeat domain crucial for protein-protein interactions.

Purpose of the Study:

  • To review recent advancements in understanding Cdc20 functions.
  • To elucidate mechanisms of APC/C activation by Cdc20.
  • To summarize Cdc20 regulation by phosphorylation and binding proteins.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of molecular mechanisms of APC/C activation.
  • Examination of regulatory pathways involving Cdc20.

Main Results:

  • Cdc20 activates the anaphase-promoting complex/cyclosome (APC/C) to target securin and cyclin B for degradation.
  • This activation promotes anaphase onset and mitotic exit.
  • Cdc20 integrates signals from the spindle checkpoint and cytostatic factor (CSF).

Conclusions:

  • Cdc20 is a central integrator of mitotic signaling pathways.
  • Understanding Cdc20's regulation is key to comprehending cell cycle control.
  • Further research on Cdc20 and APC/C interactions offers insights into cell division processes.