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Effects of normal blood pressure, prehypertension and hypertension on left ventricular diastolic function and aortic

Dogan Erdogan1, Mustafa Caliskan, Ibrahim Yildirim

  • 1Suleyman Demirel University, Medical Faculty, Cardiology Department, Isparta, Turkey. aydoganer@yahoo.com

Blood Pressure
|July 7, 2007
PubMed

Insights

Prehypertension (PHT) and hypertension significantly impair aortic elasticity, with PHT showing similar severity to hypertension. Left ventricular diastolic function is slightly impaired in PHT.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • The Seventh Report of the Joint National Committee (JNC) established new blood pressure (BP) categories: normal, prehypertension (PHT), and hypertension.
  • While PHT increases the risk of developing hypertension, its impact on target-organ damage remains unclear.
  • This study investigates the effects of normal BP, PHT, and hypertension on left ventricular (LV) diastolic function and aortic elasticity.

Purpose of the Study:

  • To evaluate the impact of normal BP, PHT, and hypertension on LV diastolic function.
  • To assess the effects of normal BP, PHT, and hypertension on aortic elastic properties.
  • To determine if PHT predisposes individuals to target-organ damage.

Main Methods:

  • Transthoracic echocardiography was used to assess LV diastolic function and aortic elastic properties.
  • The study included 60 subjects with PHT, 70 patients with hypertension, and 50 healthy normotensive volunteers.
  • Participants with any systemic disease were excluded.

Main Results:

  • LV diastolic function was significantly more impaired in the hypertension group compared to the PHT and control groups.
  • Aortic distensibility was significantly lower and aortic stiffness index significantly higher in both PHT and hypertension groups versus controls.
  • Aortic elastic properties did not significantly differ between the PHT and hypertension groups, with PHT predicting impaired aortic elasticity.

Conclusions:

  • Aortic elastic properties are significantly impaired in individuals with PHT, comparable in severity to hypertension.
  • LV diastolic function shows slight impairment in subjects with PHT.
  • Impaired aortic elasticity in PHT suggests potential for target-organ damage similar to established hypertension.
Abstract

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