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Beclin 1 mRNA strongly correlates with Bcl-XLmRNA expression in human hepatocellular carcinoma
F Daniel1, A Legrand, D Pessayre
1Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 481, Université Paris 7, Paris, France. fdaniel@bichat.inserm.fr
Abstract:
Beclin 1 physically associates with Bcl-x(L) and is considered as a haploinsufficient tumor suppressor. As the role of Beclin 1 in hepatocellular carcinoma (HCC) is unknown, we determined Beclin 1 mRNA expression in 27 pairs of tumoral/nontumoral (T/NT) liver samples. The Beclin 1 mRNA T/NT ratio was less than 0.5 in 2 tumors and more than 2 in 1 tumor, and was positively correlated with the Bcl-X(L) mRNA T/NT ratio (P < 0.001), but not with the proliferating cell nuclear antigen mRNA T/NT ratio. Coregulation of Beclin 1 and Bcl-X(L) expression in HCC may suggest cooperation in the regulation of apoptosis.
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