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Updated: Jul 13, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Liver fibrosis and chronic viral hepatitis
Gabriela Gutierrez-Reyes1, Maria Concepcion Gutierrez-Ruiz, David Kershenobich
1Departamento de Medicina Experimental, Hospital General de México, Universidad Nacional Autónoma de México, México, D.F., México. gabgurey@yahoo.com.mx
Abstract:
Liver fibrosis results from chronic damage to the liver in conjunction with the progressive accumulation of fibrillar extracellular matrix proteins. Fibrosis progression in patients with chronic viral hepatitis is a dynamic process where hepatic stellate cells, the most important contributor cell type, respond to a variety of host genetic factors and viral proteins. The abuse of alcohol, superimposed fatty liver disease, and age at the time of viral infection are some of the factors that accelerate liver fibrosis. Liver biopsy remains the gold standard to diagnose fibrosis and significant advances have been made to develop noninvasive markers for liver fibrosis.
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