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Updated: Jul 13, 2026

Methylated DNA Immunoprecipitation
Published on: January 2, 2009
Cancer genetics of epigenetic genes
Ahmad Miremadi1, Mikkel Z Oestergaard, Paul D P Pharoah
1Cancer Genomics Program, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK.
Abstract:
The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.
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