Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New cyclodextrin bioconjugates for active tumour targeting.

Stefano Salmaso1, Sara Bersani, Alessandra Semenzato

  • 1Department of Pharmaceutical Sciences, University of Padova, Padova, Italy.

Journal of Drug Targeting
|July 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Bespoke doxorubicin-loaded gold nanoparticles for ultrasound-guided cancer cell killing" [Biomed. Pharmacother. 193 (2025) 118777].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Extracellular Vesicles From Mesenchymal Stromal Cells Drive Muscle and Neuronal Regeneration Through TNFα Modulation.

Journal of extracellular vesicles·2026
Same author

Ocular delivery of different valosin-containing protein (VCP) inhibitory formulations prevents retinal degeneration in rho<sup>∆I255</sup> mice.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study.

BMC medicine·2026
Same author

Folate-targeted gold nanoparticles for doxorubicin delivery in tumor spheroids.

Drug delivery·2025
Same author

Functional and therapeutic effects of Glabrescione B delivery by liposomes on Hedgehog-dependent tumors.

Drug delivery and translational research·2025
Same journal

Tubulin as a Well-Established Yet Underexploited Target: New Opportunities for Drugs Repurposing?

Journal of drug targeting·2026
Same journal

Physcion-loaded, folic acid-conjugated DSPE-PEG liposomes for targeted therapy of ulcerative colitis.

Journal of drug targeting·2026
Same journal

Enzyme-responsive 2-dimensional nanomaterials for targeted breast cancer treatment.

Journal of drug targeting·2026
Same journal

Integrating antibody-drug conjugates, multispecific antibodies, targeted protein degradation and nanomedicine in precision oncology.

Journal of drug targeting·2026
Same journal

Nanomaterials for subcellular organelle targeting: unlocking new avenues for enhanced therapeutic effectiveness.

Journal of drug targeting·2026
Same journal

Eletriptan HBr-loaded solid lipid nanoparticle-integrated microneedles: a targeted and minimally invasive approach for migraine management.

Journal of drug targeting·2026
See all related articles

A novel cyclodextrin carrier functionalized with folic acid (FA) enhances drug solubility and stability. This targeted delivery system shows selectivity for folate receptor-overexpressing tumor cells, improving drug efficacy.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Poor solubility and degradation limit the efficacy of many therapeutic drugs.
  • Active targeting strategies are crucial for enhancing drug delivery to specific cells, particularly cancer cells.
  • Cyclodextrins offer potential as drug carriers but require modification for improved functionality and targeting.

Purpose of the Study:

  • To synthesize and characterize a novel cyclodextrin-based carrier for active targeting of poorly soluble and degradable drugs.
  • To evaluate the drug solubilization, stabilization, and targeting capabilities of the new carrier system.
  • To assess the carrier's selectivity towards folate receptor-overexpressing tumor cells.

Main Methods:

  • Synthesis of a beta-cyclodextrin derivative functionalized with hexamethylene diisocyanate and polyethylene glycol (PEG).

Related Experiment Videos

  • Functionalization of the PEG chain with folic acid (FA) for tumor targeting.
  • Characterization using NMR, chromatography, and spectroscopy.
  • Evaluation of drug solubility, degradation, and complexation with curcumin.
  • In vitro assessment of targeting specificity using KB and MCF7 cell lines.

    • Main Results:

    • The modified cyclodextrin carrier (CD-(C6-PEG)5-FA) showed reduced hemolytic activity compared to native beta-cyclodextrins.
    • Significant increase in beta-estradiol and curcumin solubility (300-3200 fold) and decreased degradation rates for chlorambucil and curcumin.
    • Formation of a stable inclusion complex with curcumin with a high association constant.
    • Demonstrated potential selectivity for folate receptor-overexpressing tumor cells in vitro.

    Conclusions:

    • The synthesized cyclodextrin-based carrier effectively enhances the solubility and stability of poorly soluble drugs.
    • Folic acid functionalization provides active targeting capabilities towards folate receptor-positive tumor cells.
    • This novel drug delivery system holds promise for improving the therapeutic efficacy of challenging drug candidates.