Related Experiment Video
Updated: Jul 13, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Formulation study of oxybutynin patches
Paola Minghetti1, Francesco Cilurzo, Stefania Pagani
1Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Milano, Italy. paola.minghetti@unimi.it
Abstract:
The present feasibility study was designed to obtain a monolayer patch containing oxybutynin (OXY) avoiding chemical permeation enhancers. The highest flux was obtained with a polydimethylsiloxane matrix patch. Because OXY crystals were detected in the matrix within a week, two amino methylmethacrylate copolymers (Eudragit E or Eudragit RS) were used as OXY crystallization inhibitors. A preliminary in vivo study indicated that flux from the stabilized patches had to be increased about 30-40%. This goal was reached by occlusion with a polyethylene layer.
Related Concept Videos
Ophthalmic Drug Delivery Systems
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Oral Drug Delivery Systems: Continuous-Release Systems
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Cholinergic Antagonists: Pharmacokinetics
Bioavailability Enhancement: Drug Permeability Enhancement