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Ossifying fibromyxoid tumor: invariable ultrastructural features and diverse immunophenotypic expression
Takanori Hirose1, Shio Shimada, Takayuki Tani
1Department of Pathology, Saitama Medical School, Saitama, Japan. thirose@saitama-med.ac.jp
Ultrastructural Pathology
|July 7, 2007
Summary
Ossifying fibromyxoid tumors (OFMT) are rare soft tissue neoplasms. This study details 3 adult cases, highlighting their nodular structure, bone formation, and potential for recurrence or metastasis.
Area of Science:
- Pathology
- Oncology
- Soft Tissue Neoplasms
Background:
- Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm with uncertain origins.
- Understanding OFMT's characteristics is crucial for accurate diagnosis and patient management.
Observation:
- Three adult cases of OFMT in the trunk and head/neck regions were analyzed.
- Tumors presented as multiple nodules with tumor cells in a fibromyxoid stroma.
- Characteristic shell-like bone formation was observed in all cases.
Findings:
- Two OFMT cases were graded as malignant, and one as typical, using Folpe et al.'s system.
- Immunohistochemistry revealed S-100 protein, cytokeratin, and neuronal markers.
- Ultrastructural analysis consistently showed reduplicated basal laminas, a key diagnostic feature.
Implications:
- These findings contribute to the understanding of OFMT pathology and behavior.
- Accurate grading and diagnosis, aided by ultrastructural features, are vital for predicting OFMT outcomes.
- Further research into OFMT origins and metastatic potential is warranted.
