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Related Experiment Videos

Physical activity, Cdx-2 genotype, and BMD.

P Gentil1, R M Lima, T C L Lins

  • 1Programa de Pós Graduação em Educação Física, Universidade Católica de Brasília, Taguatinga, Brazil. paulogentil@hotmail.com

International Journal of Sports Medicine
|July 7, 2007
PubMed
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This study found that the Cdx-2 polymorphism alone does not affect bone mineral density (BMD) in postmenopausal women. However, physical activity levels interact with the Cdx-2 genotype to influence BMD, particularly in active women with the Cdx-G/G genotype.

Area of Science:

  • Genetics and Bone Health
  • Exercise Physiology
  • Postmenopausal Health

Background:

  • Bone mineral density (BMD) loss is a significant concern for postmenopausal women, increasing fracture risk.
  • Genetic factors, such as Cdx-2 polymorphism, and lifestyle factors, like physical activity, may influence BMD.
  • Understanding these interactions is crucial for developing targeted interventions to maintain bone health.

Purpose of the Study:

  • To investigate the interaction between Cdx-2 polymorphism and physical activity level on bone mineral density (BMD) in Brazilian postmenopausal women.
  • To determine if Cdx-2 genotype influences BMD independently or in conjunction with physical activity.
  • To explore potential genetic predispositions to physical activity's effects on bone health.

Main Methods:

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  • A cohort of 190 Brazilian postmenopausal women (mean age 66.6 years) was studied.
  • Physical activity level (PAL) was assessed using the International Physical Activity Questionnaire (IPAQ).
  • BMD was measured at the lumbar spine, femoral neck, great trochanter, and Wards' triangle using dual-energy X-ray absorptiometry (DXA).
  • Cdx-2 polymorphism was genotyped using minisequencing.
  • Statistical analyses examined the association between Cdx-2 genotype, PAL, and BMD.

Main Results:

  • No significant association was found between Cdx-2 polymorphism and adjusted BMD at any measured site when considered alone.
  • A significant interaction was observed between physical activity level (PAL) and Cdx-2 genotype concerning adjusted femoral neck and Wards' triangle BMD.
  • Active women with the Cdx-G/G genotype exhibited higher adjusted femoral neck and Wards' triangle BMD compared to inactive women with the same genotype.
  • These findings suggest that the Cdx-G/G genotype may enhance the positive effects of physical activity on specific BMD sites.

Conclusions:

  • The Cdx-2 polymorphism does not appear to influence BMD in postmenopausal women independently.
  • The Cdx-2 genotype modulates the response of bone mineral density to physical activity.
  • Individuals with the Cdx-G/G genotype may experience a more pronounced bone mineral density benefit from regular physical activity, highlighting a gene-environment interaction in bone health management.