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CRISPR-mediated Genome Editing of the Human Fungal Pathogen Candida albicans
09:56

CRISPR-mediated Genome Editing of the Human Fungal Pathogen Candida albicans

Published on: November 14, 2018

Genetics of Candida albicans, a diploid human fungal pathogen

Suzanne M Noble1, Alexander D Johnson

  • 1Department of Microbiology and Immunology, University of California-San Francisco, CA 94143-2200, USA. Suzanne.Noble@ucsf.edu

Annual Review of Genetics
|July 7, 2007
PubMed

Insights

Candida albicans, a common fungus, can cause infections in healthy individuals and severe disease in immunocompromised patients. Recent advances in genetics and technology are revealing insights into its biology.

Area of Science:

  • Medical Mycology
  • Microbial Pathogenesis
  • Population Genetics

Background:

  • Candida albicans is a prevalent human fungal pathogen.
  • It causes superficial infections in healthy individuals and invasive diseases in immunocompromised patients.
  • Understanding its persistence and virulence is crucial for clinical and economic reasons.

Purpose of the Study:

  • To review recent advancements in understanding Candida albicans biology.
  • To highlight new insights from population genetics, mating processes, and gene disruption technologies.

Main Methods:

  • Review of recent literature on Candida albicans.
  • Focus on population genetics studies.
  • Discussion of advancements in mating process research.
  • Exploration of gene disruption technologies.

Main Results:

  • Recent developments offer experimental insights into C. albicans biology.
  • Population genetics and gene disruption technologies are key tools.
  • Understanding of C. albicans pathogenesis is improving.

Conclusions:

  • New genetic and technological approaches are crucial for studying Candida albicans.
  • Further research is needed to fully understand its dual role as a commensal and pathogen.

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